IndraLab

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"Binding of Rfx3 to Abcc8 or voltage-dependent Ca 2+ channel genes has not been reported, and although Rfx6 and Rfx3 might coregulate other targets genes, the extent of the functional redundancy of both transcription factors in β cell function and insulin secretion cannot be evaluated, as the phenotype of mice with a deletion of  Rfx3 in adult β cells has not been described."