IndraLab

Statements

UCHL5 activates TGFB1. 5 / 11
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"All these data show that UCHL5 stabilizes Smad2 and Smad3, and promotes TGFbeta-1 signaling."
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"b-AP15, an inhibitor of UCHL5, attenuates TGFbeta-1 signaling and diminishes pulmonary fibrosis in a bleomycin induced pulmonary fibrosis model."
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"UCHL5 stabilizes Smad2 and Smad3 and promotes TGFbeta-1 signaling."
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"In addition, UCH37 stabilizes Smad2/3 and promotes TGF-b1 signal transduction (39) ."
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"In this study, we reveal that b-AP15, an inhibitor of UCHL5, attenuates TGFbeta-1 signaling through inducing ubiquitination and degradation of Smad2 and Smad3."
27604640