IndraLab

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CCL5 binds GPR75. 11 / 11
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"Z = 1 ‐ 3 SD of sample + 3 SD of control | mean of sample ‐ mean of control | The inhibition effects of the compounds on CCL3, CCL4, CCL5, CCL7 or CCL11 binding to CCR5, as well as the CCL5 binding to[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In order to confirm these claims, SPR experiments were conducted on GPR75 immobilized sensors to reveal a specific interaction between CCL5 and GPR75 (Figure 2a)."
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"The inability of CCL5 to promote increases in iCa , in the presence of abundant GPR75, suggests that the protein–protein interaction between CCL5 and GPR75 potentially sequesters CCL5 and renders it incapable of interacting with its canonically associated CCRs and therefore changes in Ca signalling cannot be observed."
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"As introduced before, CCL5 is an extremely powerful chemoattractant with a physiologic role in recruiting immune cells in inflammatory or allergic circumstances [26] CCL5 binds with high affinity to its main receptor CCR5, but also to CCR1, -3, -4, CD44 and GPR75."
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"Moreover, we showed that CCL5 binds to GPR75 but fails to activate its signaling."
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"These results support our previous observations suggesting that CCL5 binding to GPR75 prevents 20-HETE from activating the receptor."
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"Furthermore, in line with previous reports (Southern et al., 2013), CCL5 was unable to increase recruitment of β-arrestin to GPR75, providing additional evidence that although CCL5 can bind to GPR75, it does not induce any conventional or biased agonist signal through the receptor."
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"The dynamic interaction between 20-HETE, CCL5 and GPR75 is striking and speaks to the complexity and intricate nature of all receptor interactions and their respective signalling outcomes."
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"Interestingly, other reports have identified an interaction between the chemokine CCL5/RANTES and GPR75, suggesting that CCL5 drives calcium influx and can stimulate insulin secretion from pancreatic islets through GPR75."
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"Further studies are necessary to more fully characterize CCL5/RANTES binding to GPR75 and whether it acts as an antagonist for 20-HETE binding."
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"CCL5 binds with high affinity to its receptor CCR5, but it also binds CCR1, CCR3, CCR4 [27,28], CD44 [27,29], and GPR75 [30]."
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