IndraLab

Statements

COPS6 leads to the deubiquitination of SLC22A1. 3 / 3
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"Moreover, overexpression of CSN6 reduced OCT1 ubiquitination, while ectopic expression of TRIM21 reversed this effect."
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"Simultaneously, knockdown of CSN6 increased OCT1 ubiquitination, while knockdown of TRIM21 reversed this impact."
32225170
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"In colorectal cancer, COP9 signalosome subunit 6 (CSN6) facilitates ubiquitin-mediated tripartite -motif protein 21 (TRIM21) degradation, reducing TRIM21-mediated organic cation transporter subtypes 1 (OCT1) ubiquitination, stabilizing OCT1, and promoting CSCs [94]."
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