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USP9X deubiquitinates ERG. 7 / 7
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"Previously, we found that ERG undergoes ubiquitination and then is deubiquitinated by USP9X in prostate cancer cells to prevent its proteasomal degradation."
27626314
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"Here, we show that ubiquitin specific peptidase 9, X linked (USP9X), a deubiquitinase enzyme, binds ERG in VCaP prostate cancer cells expressing TMPRSS2-ERG and deubiquitinates ERG in vitro."
24591637
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"USP9X binds to the ETS domain in ERG protein; therefore, USP9X deubiquitinates and stabilizes full-length ERG and TMPRSS2 - ERG fusion gene products."
30217566
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"Wang et al. demonstrated that ubiquitin specific peptidase 9, X linked (USP9X), a deubiquitinase enzyme, binds ERG in VCaP prostate cancer cells expressing TMPRSS2-ERG and deubiquitinates ERG in vitro XREF_BIBR."
27208692
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"A role for ERG ubiquitination in prostate cancer cells was also demonstrated by Wang et al. who showed that the enzyme USP9X, which is highly expressed in ERG positive prostate tumours, mediates ERG deubiquitination and thus its stabilization XREF_BIBR."
27208692
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"Indeed, previous reports have shown Usp9x deubiquitinates and stabilizes ERG, and our previously described DUB inhibitor (WP1130) demonstrated anti-tumour efficacy in ERG driven prostate cancer XREF_BIBR."
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"we show that ubiquitin-specific peptidase 9, X-linked (USP9X), a deubiquitinase enzyme, binds ERG in VCaP prostate cancer cells expressing TMPRSS2-ERG and deubiquitinates ERG in vitro."
24591637