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SJB2-043 inhibits USP1. 6 / 6
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"USP1 inhibitor SJB2-043 inhibits the enzyme activity of native USP1."
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"We next determined whether SJB2-043 inhibits the DUB activity of native USP1 complexes isolated from human cells (XREF_FIG)."
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No evidence text available
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"These results demonstrate that USP1 inhibitor SJB2-043 inactivates native USP1 in primary AML cells and exhibits cytotoxicity."
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"SJB2-043 blocked the deubiquitinating enzyme activity of USP1 in vitro with an IC50 in the nanomolar range (Mistry et al., 2013)."
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"In addition, SJB2-043 inhibited the labeling of USP1 with Ub-VS in a dose dependent manner (XREF_SUPPLEMENTARY)."
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