IndraLab

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USP11 inhibits KLF4. 6 / 6
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"Furthermore, our results also showed that high USP11 levels inhibit KLF4 stability and expression."
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"USP11 degrades KLF4 via its deubiquitinase activity in liver diseases."
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"We also provide mechanistic insights into KLF4 degradation and show that USP11 depletion inhibits growth and chemoresistance of HCC cells by enhancing KLF4 stability."
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"USP11 degrades KLF4 via its deubiquitinase activity in liver diseases ."
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"USP11 destabilizes KLF4 through the removal of K63-dependent polyubiquitination , thereby inhibiting KLF4 expression ."
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"Altogether, these results indicate that USP11 is a KLF4‐specific deubiquitinase that promotes KLF4 degradation.3.3 USP11 mediates cancer cell proliferation and tumorigenesis by promoting KLF4 instability."
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