IndraLab

Statements

KCNA2 inhibits Neuralgia. 10 / 11
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"For example, Kcna2 antisense lncRNA is expressed in DRG neurons and causes or reduces NP through its ability to regulate the voltage-dependent potassium channel, Kcna2, impacting neuronal excitability (Zhao et al., 2013)."
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"To further examine the hypothesis that reducing Kv1.2 expression induces neuropathic pain, Kv1.2 expression in rats was inhibited by injecting Kv1.2-siRNA (dissolved in enzyme-free water) into the left VPL."
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"We recently reported that Kv1.2 AS RNA as a trigger contributes to neuropathic pain development and maintenance by specifically silencing Kv1.2 mRNA in the DRG [16]."
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"Moreover, Zhao et al. have recently identified a functional lncRNA Kcna2, which contributed to neuropathic pain by silencing Kcna2 in DRG neurons [18]."
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"Lastly, a long non-coding RNA contributes to neuropathic pain by silencing KCNA2 and thereby reducing expression of K 1.2 in primary afferents (Zhao et al., 2013)."
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"The upregulation of Kcna2 antisense RNA, a conserved lncRNA, in injured DRG ultimately suppresses neuropathic pain symptoms (Zhao et al., 2013)."
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"A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons."
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"We found that Kcna2 antisense RNA may act as a biologically active regulator and participate in induction and maintenance of neuropathic pain by specifically silencing Kcna2 expression in the DRG."
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"1ZhaoXTangZZhangH A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons."
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"Knockdown of Kv1.2 or Kv9.1 in naïve animals induces pain hypersensitivity , and overexpression of Kv1.2 or Kir2.1 reduces neuropathic pain ."
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