IndraLab

Statements

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits RELA. 2 / 2

| 2

reach

"In hHM, P6 inhibits RelA-P-Ser536, but not RelA, nuclear translocation, which provides an explanation as to why P6 only affects a subset, and not all, of NF-kappaB-regulated inflammatory genes."

22996371

➶

reach

"We can not rule out the possibility that P6 disrupts RelA complexes with IKK, other kinases or coactivators, or changes dimer composition to exert its effects."

22996371

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits RELA. 2 / 2

INDRA sources:

Databases

Reading