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Doxorubicin inhibits NFKBIA. 8 / 8
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"More specifically, the knockdown of IKKalpha and IKKbeta blunted the ability of doxorubicin to initiate the degradation of IkappaBalpha as well as decreased the phosphorlyation of p65 at the serine536 residue following doxorubicin treatment."
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"Interestingly, the knockdown of either catalytic subunit resulted in an increase in IkappaBalpha at baseline (XREF_FIG) as well as a decrease in the doxorubicin induced degradation of IkappaBalpha (XREF_FIG)."
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"To this end, experiments were performed to determine whether doxorubicin induced degradation of IKB-alpha, an endogenous inhibitor of NF-kappaB translocation to the nucleus and subsequently NF-kappaB activity."
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"Consistently with our previous findings in other cancer cells [XREF_BIBR], doxorubicin induced IkappaBalpha degradation, p65 nuclear localization and increased NF-kappaB -DNA binding in the triple negative MDA-MB-231 cells."
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"Recently, it has also been shown that doxorubicin can initiate IkappaBalpha degradation and NF-kappaB activation independent of either IKKalpha or IKKbeta using the same in vitro models."
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"To determine whether low-dose doxorubicin upregulates NF-kappaB activity by facilitating IkappaBalpha degradation, the protein levels of cytosolic IkappaBalpha and nuclear NF-kappaB were determined by[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, pretreatment of wortmannin blocked etoposide and doxorubicin induced IkappaB-alpha degradation, NFkappaB activation, phosphorylation of Akt, MDM-2 and forkhead transcription factors."
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"Doxorubicin activates NF-kappaB and induces IkappaBalpha degradation in HT1080 cells."
18644995