IndraLab

Statements

USP35 binds FUNDC1. 8 / 8
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"Mechanistically, USP35 interacted with and stabilized FUNDC1, a positive regulator of mitochondrial metabolism."
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"USP35 interacted with and stabilized FUNDC1 by repressing its ubiquitination."
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"The data from these assays indicated a direct interaction between USP35 and FUNDC1 within the cells (Fig. 4D)."
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"Mechanistically, it was discovered that USP35 interacted with FUNDC1 and executed deubiquitination processes, thereby enhancing the stability of FUNDC1."
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"The data from these assays indicated a direct interaction between USP35 and FUNDC1 within the cells (Fig.  xref )."
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"This highlights the critical role of the USP35-FUNDC1 axis in enhancing the neuroprotective function of both hUC-MSCs and their secreted EVs (Fig.  xref )."
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"However, the specific domain of FUNDC1 that interacts with USP35 has yet to be identified."
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"These findings not only expand our understanding of the mechanisms underlying the beneficial effects of hUC-MSC and hUC-MSC-EV in mitigating CIRI and the regulation of FUNDC1 metabolism but also highlight the USP35-FUNDC1 axis as a therapeutical target for the treatment of symptoms arising from CIRI."
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