IndraLab

Statements

COPS6 activates CTNNB1. 9 / 9
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"Because KRAS is an upstream regulator of these two pathways, KRAS mutations will continue to activate both RAS-MAPK and AKT pathways to stabilize CSN6, which in turn activates beta-catenin activity to cause pathogenesis in colon cancer."
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"Here, we provided another example of CSN6 preserved Cullin neddylation in affecting another F-box protein -- beta-Trcp and showed how CSN6 can destabilize beta-Trcp and subsequently increase the stability of beta-catenin."
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"The TOP-FLASH TCF/LEF -1 luciferase reporter gene analyses showed that Flag-CSN6 significantly increased beta-catenin transactivation, but the activity of Flag-CSN6-S148A was compromised."
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"Furthermore, we demonstrate that CSN6 enhances beta-catenin stability and that the CSN6 associated protein beta-Trcp negatively regulates beta-catenin stability."
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"CSN6 Positively Regulates beta-Catenin Protein Stability and Facilitates the Transcriptional Activity of beta-Catenin."
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"Given that CSN6 positively regulates beta-catenin by regulating beta-Trcp ubiquitination, 41 CSN6 may also regulate ALDH1A1 expression through the beta-catenin pathway."
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"The TOP-FLASH TCF/LEF -1 luciferase reporter gene analyses showed that Flag-CSN6 significantly increased beta-catenin transactivation but the activity of Flag-CSN6-S148A was compromised (XREF_FIG)."
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"Downregulation of CSN6 attenuates papillary thyroid carcinoma progression by reducing Wnt and beta-catenin signaling and sensitizes cancer cells to FH535 therapy."
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"CSN6 positively regulates beta-catenin protein stability and facilities the EMT in PTC cells."
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