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OTUB1 inhibits CCN6. 6 / 6
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"We found that OTUB1 ablation decreased CCN6 protein abundance only in the non‐endoplasmic reticulum fraction (Figure S3A)."
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"Upon treatment with cycloheximide, the ablation of OTUB1 significantly accelerated the degradation of CCN6 in 4T1 cells (Figure 2A)."
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"In this study, we found that OTUB1 inhibited the aggressive phenotypes of breast cancer by stabilizing CCN6, a specific and potent suppressor in breast cancer."
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"This suggests that OTUB1 inhibits proteasome‐dependent degradation of CCN6."
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"Similar to Figure 6A, OTUB1 deficiency significantly increased tumour weight whereas supplementation of CCN6 abolished the effect of OTUB1 deletion on tumour weight (Figure 6C), suggesting that OTUB1 inhibits tumour growth primarily by increasing CCN6."
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"OTUB1 inhibits breast cancer by non-canonically stabilizing CCN6."
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