IndraLab

Statements

COPS5 inhibits cell death. 4 / 4
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"Thus, disruption of the Jab1 gene not only abolished JAB1 expression but also increased p27, p53 and c-Myc levels and cell death, suggesting that JAB1 is involved in maintaining the integrity and stability of critical regulators of cell proliferation and apoptosis."
20802511
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"However, the molecular mechanisms by which loss of JAB1 leads to cell death are still unclear."
20802511
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"Deletion of both Jab1 alleles caused embryonic lethality and accelerated cell death in blastocysts, indicating the essential role of Jab1 during mouse development."
20802511
reach
"CSN5 knockdown caused mitotic defects, G2/M arrest and apoptotic cell death."
19400951