IndraLab

Statements

USP1 inhibits DNA repair. 4 / 4
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"Mutation of aspartic acid 199 in USP1 disrupts its deubiquitinating activity and impairs DNA repair."
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"Initial evidence suggested that USP1 inhibition leads to constitutive DNA repair and protects cells from MMC induced chromosome aberrations [45]."
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"USP1 levels decrease after DNA damage, leading to a transient elevation of Ub-FANCD2 levels and to increased DNA repair ( Nijman et al., 2005a )."
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"In conclusion, USP1 is likely to play an important role in the DNA damage response pathway, thereby becoming a promising therapeutic target for liver cancer.The above bioinformatics analysis indicates that the expression of USP1 is negatively correlated with therapeutic effect in liver cancer patients in clinic, indicating the use of USP1i such as C527 to inhibit the USP1 expression is possible to inhibit DNA repair, resulting in increasing DNA damage caused by DNA alkylating agents such as cisplatin, finally enhancing the anti-tumor effect."
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