IndraLab

Statements

ARSD binds USP4. 3 / 3
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"We observed that ASD binds to the UBL2 region of USP4, which interacts with the DUSP and ubiquitin‐like 1 domains and is required for USP4 activation [ xref ]."
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"ASD interacts with USP4 and promotes the deubiquitination of peroxisome proliferator‐activated receptor gamma, thus inhibiting its proteasomal degradation and enhancing the transcriptional activation of UCP1 in brown adipocytes."
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"Microscale thermophoresis experiment showed that the affinity constant of ASD binding with USP4 was 37.8 ± 28.0 µM (Figure  xref )."
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