IndraLab

Statements


Mutated USP4 deubiquitinates BRCA1. 2 / 2
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reach
"Clinical USP4 mutations from human breast cancer are defective in deubiquitinating and stabilizing BRCA1."

reach
"Interestingly, like L310R and S315C, R559W mutant still can destabilize BRCA1 despite of its ability to interact with BRCA1.Next, we asked whether these USP4 mutants could deubiquitinate BRCA1."