IndraLab

Statements

USP28 increases the amount of LIN28A. 2 / 2
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"Notably, USP28 knockout alone in the NCCIT cells was insufficient to completely reduce Lin28A protein expression, indicating additional regulatory mechanisms."
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"Given that the degradation of Lin28A was by the proteasomal pathway, this could explain the stability of Lin28A protein as USP28 deubiquitinase was also downregulated at high RSV concentrations, and at 72 and 96 h. Inhibition of USP28 using siUSP28 decreases the levels of Lin28A, but the reduction is less pronounced compared to the decrease observed after RSV treatment."
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