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Mice increases the amount of USP19. 2 / 2
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"In vivo experiments in mice suggested that TIPE3 inhibited apoptosis of tumor cells and promoted macrophage M2-type polarization in tumor tissues by up-regulating the protein expression of USP19."

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"Ogawa et al. report that E2 treatment of ovx mice decreased the ratio of skeletal muscle mass to body weight and increased ubiquitin-specific peptidase 19 expression, indicating that E2 inhibits myogenesis in vivo."