IndraLab

Statements

Benzamide activates KCNH2. 2 / 2
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"ICA-105574 (ICA), a 3-Nitro-n-(4-phenoxyphenyl) benzamide derivative activates hERG1 by strongly attenuating pore-type inactivation."
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"Of these, M4K2127 showed good permeability into the brain as well as homogeneous distribution into the pons, the region of interest for DIPG, though low metabolic stability limits its further development.Alternatively, the increased polarity of benzamide analogue 3 was able to reduce moderate off-target affinity for the hERG ion channel."
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