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Calcium(2+) inhibits STING1. 5 / 5
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"It has previously been reported that STING-mediated induction of IFNβ is blocked by intracellular calcium chelation ."
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"Mechanically, deficiency in the Ca sensor stromal interaction molecule 1 (STIM1) activates STING spontaneously with subsequently increased type I interferons in immunodeficient mice [48]."
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"Paradoxically, cytosolic Ca elevation induced by ionomycin can also inhibit STING activation [30]."
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"Furthermore, ER stress during infectious, inflammatory, and autoimmune diseases increases cytosolic Ca levels, which disrupts STING-STIM-1 bonding, allowing STING to move from the ER to the ER–Golgi intermediate complex (ERGIC) and Golgi complex [120,121,122,123]."
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"Still, the mechanism linking ER stress to STING activation is unknown.Here, we show that both BAPTA-AM-mediated calcium sequestration and ionomycin-induced increases in intracellular calcium suppress [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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