IndraLab

Statements

USP22 inhibits AR. 5 / 7
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"First, depletion of USP22 significantly reduced AR protein (~ 73%) compared to control (XREF_FIG, compare lanes 3,4 and 7,8)."
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"As shown, in CRPC cells, USP22 depletion suppressed AR protein accumulation in both the androgen stimulated and deprived conditions (XREF_FIG, compare lanes 1,2 and 3,4)."
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"In androgen deprived conditions, USP22 depletion modestly decreased basal AR activity."
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"Additionally, in both culture conditions, USP22 depletion diminished AR activity (XREF_FIG)."
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"It is worth noting that the knockdown of USP22, although leading to an insignificant down-regulation of AR, allows Importin-7 to bind more AR, suggesting that USP22 is possibly one of the cargoes of Importin-7 (Fig. 4H)."
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