IndraLab

Statements

USP8 binds NFE2L2. 5 / 5
2 | 3
biogrid
No evidence text available
37639742
biogrid
No evidence text available
37639742
sparser
"At last, we illustrated that USP8 interacted with Nrf2 directly and deubiquitinated K48-linked polyubiquitin chains from Nrf2, stabilizing the expression of Nrf2."
37639742
sparser
"Cui et al. reported that USP8 bound to Nrf2 and further deubiquitinated the K48-linked polyubiquitin chains of Nrf2, which increased gemcitabine resistance in PDAC by promoting cell viability and suppressing apoptosis [ xref ]."
41102147
sparser
"In pancreatic cancer, USP8 directly interacts with NRF2, deubiquitinating and stabilizing NRF2 to drive resistance to the antimetabolite gemcitabine [ xref , xref ]."
41331709