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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

FTY720-P inhibits KCNMA1. 2 / 2

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"In particular, FTY720-P strongly induces internalization and degradation of S1P 1, inhibits S1P responsiveness of lymphocytes in the SLO, and acts as a functional antagonist at lymphocytic S1P 1."

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"Based on these results, it is highly likely that FTY720-P converted from FTY720 acts as a functional antagonist at S1P 1 by internalization and degradation of this receptor, reduces S1P responsiveness of lymphocytes in the SLO, and inhibits S1P 1 -dependent lymphocyte egress from the SLO (XREF_FIG d)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...