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Cariprazine inhibits KCNH2. 2 / 2
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"Our results indicated that cariprazine concentration-dependently inhibited hERG 1A and hERG 1A/3.1 currents by preferentially interacting with the open states of the hERG 1A channel, but not by the disruption of hERG 1A and hERG 1A/3.1 channel protein trafficking."
30954564
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"Cariprazine inhibited the hERG 1A and hERG 1A/3.1 tail currents at -50 mV in a concentration dependent manner with IC 50 values of 4.1 and 12.2 muM, respectively."
30954564