IndraLab

Statements

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"We also observed that down-regulation of USP8 inhibited the proliferation of GC cells which highly expressed HER-3."
32848421
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"In order to find out whether the pharmacological inactivation of USP8 could inhibit the growth of GC cells and was related to HER-3, USP8 inhibitor (DUBs-IN-2, XREF_FIG) was applied to evaluate the antiproliferation activity in these cell lines in XREF_FIG."
32848421
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"All in vitro results demonstrated that down-regulation of USP8 inhibited the proliferation and viability of GC cells with high expression of HER3 (NCI-N87, MKN-45 and AGS), but did not affect HER3 negative cells (MGC-803)."
32848421
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"The USP8 inhibited HER-2 positive GC cell proliferation and migration in vivo and in vitro and probably served as a novel potential therapeutic biomarker for HER-2 positive GC."
33116578
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"More interestingly, knockdown of USP8 was reported to induce apoptosis of HER3-positive GC cells and reduce the cell growth or viability by arresting the cell cycle [ 56 ]."
33600786
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"XREF_BIBR, XREF_BIBR Therefore, it can be inferred that down-regulation of USP8 may inhibit the proliferation and even metastasis of GC through this pathway."
32848421