IndraLab

Statements

USP20 activates CTNNB1. 3 / 3
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"USP20 and USP4 induce drug resistance in breast cancer and colorectal cancer cells by stabilizing β-catenin, the key modulator of the Wnt pathway [249, 250]."
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"Previous publications have identified β-catenin as an oncogene [62], prompting us to speculate that USP20 promotes tumorigenesis by regulating β-catenin stability."
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"USP20 and USP4 promote the stability of β-catenin, thus continuously activating the Wnt-β-catenin signaling pathway and mediating drug resistance in breast cancer and CRC ( Fig. 3 )."
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