IndraLab

Statements

BAP1 leads to the ubiquitination of ASXL2. 4 / 4
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"Thus, BAP1 promotes the ubiquitination of its co-factor ASXL2 regulating its stability, and this in turn regulates the enzymatic activity and function of the DUB complex."
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"BAP1 promotes ASXL2 monoubiquitination on its DEUBAD domain."
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"As BAP1 promotes ASXL2 monoubiquitination in vivo, we evaluated whether BAP1 with E2-conjugating enzymes are sufficient to direct this event in vitro."
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"Our results, obtained from cell-based studies, suggest that BAP1 might either directly stimulate ASXL2 monoubiquitination or preserve monoubiquitinated ASXL2 from degradation."
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