IndraLab

Statements

E6 decreases the amount of CYLD. 3 / 3
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"Transient transfection studies involving E6 and Flag tagged CYLD constructs in HEK293 cells demonstrated that CYLD expression was reduced by E6 in a dose dependent manner (XREF_FIG)."
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"E6 reduces CYLD expression through a proteasome dependent mechanism."
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"Thus, in ambient oxygen tension, E6 gene silencing in HPV positive cells led to NF-kappaB and IKKbeta activation and increased CYLD expression, whereas ectopic expression of E6 in HPV negative cells resulted in NF-kappaB activation and CYLD degradation."
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