IndraLab

Statements

USP7 decreases the amount of USP7. 4 / 9
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"As shown in Fig. 3a, transfection of USP7 siRNA for 48 h dramatically reduced USP7 protein level to 33.8% of control (P < 0.05), whereas non-targeting siRNA did not affect USP7 protein level.Fig."
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"However, a related study showed that inhibiting USP7 increased the expression of PD-L1 in lung cancer cells (Dai et al., 2020), and higher levels of USP7 promoted tumor growth by altering the immunosuppressive characteristics of Forkhead box protein P3 (Foxp3) Treg (Gao et al., 2023)."
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"The expressions of USP7, NLRP3, GSDMD-N, active caspase-1, pro-caspase-1, MMP1, and MMP13, which was attenuated by USP7 KD or USP7 inhibitor (XREF_FIG), were significantly enhance by the H 2 O 2 treatment as shown in western blotting results."
33584299
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"ELISA and Western blotting results indicated that USP7 overexpression significantly increased IL-1beta and IL-18 levels as well as the expression of USP7, NLRP3, GSDMD-N, active caspase-1, pro-caspase-1, MMP1, and MMP13, which was decreased by USP7 KD or apocynin (XREF_FIG)."
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