IndraLab

Statements


Mutated CYLD activates NFkappaB. 3 / 3
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"Our data also suggest that TRAF3 or CYLD mutations harbor episomal HPV and have activated NF-kappaB, which may be required for episomal maintenance."

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"On the other hand, ectopic expression of CYLD mutants was found to elevate NF-kappaB activity in NPC cells, thus demonstrating a mutational drive for NF-kappaB signaling by CYLD aberrations in NPC."

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"Our data also suggest that TRAF3 or CYLD mutations harbor episomal HPV and have activated NF-kappaB that may be required for episomal maintenance."