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P5091 inhibits Mice. 2 / 2

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"As expected, mice in which USP7 activity was inhibited by P5091 showed dramatically increased susceptibility to Salmonella typhimurium."

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"Interestingly, systemic injection of P5091 abolished locomotor sensitization in control mice, similar to the effect of Maged1 inactivation (Fig. 4g, h and Supplementary Fig. 10), with no effect on spontaneous locomotor activity (Supplementary Fig. 10b), and no effect on the locomotor activity of Maged1-cKO mice (Supplementary Fig. 10c)."

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P5091 inhibits Mice. 2 / 2

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