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NPPA decreases the amount of KCNQ1. 2 / 2
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"The results showed that 10 -10 and 10 -9 M ANP significantly upregulated the expression of potassium voltage gated channel, KQT like subfamily, member 1 (KCNQ1) at the protein and mRNA levels, although 10 -7 and 10 -6 M ANP significantly downregulated the expression of KCNQ1."

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"Zhang et al. showed that ANPs played a pleiotropic role in gastric cancer cell proliferation, and the physiological concentration of ANPs upregulated the expression of the potassium-voltage-gated channel and KQT-like subfamily member 1 (KCNQ1) to promote AGS cell proliferation, while the pharmacological concentration of ANP significantly downregulated KCNQ1 expression to inhibit AGS proliferation [114]."