IndraLab

Statements

TP53 activates USP2. 3 / 3
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"USP2 is upregulated by PUVA and a p53 activator, nutlin3a."
27351221
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"It would be interesting to investigate whether USP2 aggravates the resistance to other therapeutic modalities, such as ionizing radiation or ultraviolet B. Mechanistically we were able to demonstrate that the activation of p53 upregulated USP2."
27351221
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"These results suggested that activated p53 increased USP2, which in turn counteracted the pro apoptotic activity of p53, forming a negative feedback loop."
27351221