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USP37 deubiquitinates SAMHD1. 5 / 5
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"We further demonstrated that USP37 can deubiquitinate the polyubiquitin of SAMHD1 induced by TRIM21 (Fig. 5)."
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"In vitro deubiquitination analysis showed that the polyubiquitination of SAMHD1, whether induced by Vpx or TRIM21, could be deubiquitinated by USP37 purified in Escherichia coli (Fig. 5G and H)."
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"Notably, USP37 deubiquitinates SAMHD1 by directly recognizing SAMHD1 rather than by targeting the E3 ubiquitin ligase."
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"However, USP37 significantly reduced polyubiquitination of SAMHD1 induced by SIVmac239 Vpx (Fig. 4D, lanes 3 and 4)."
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"Overall, USP37 deubiquitinates SAMHD1 by recognizing SAMHD1 rather than recognizing the E3 complex."
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