IndraLab

Statements


STAT3 activates CYLD. 3 / 3
| 3

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"Importantly, STAT3 siRNA treatment induced 100% mortality of Lm infected Cyld -/- mice, thus, resembling WT mice (XREF_FIG)."

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"Accordingly, knockdown of STAT3 significantly reduced serum IL-6 levels in Lm infected Cyld -/- mice as compared to mock treated infected Cyld -/- mice as well as untreated infected Cyld -/- mice (XREF_FIG)."

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"In this model inflammatory genes were activated by STAT3 mediated induction of miR-181b-1 that targets the tumor suppressor CYLD."