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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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STAT3 activates CYLD. 3 / 3

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"Importantly, STAT3 siRNA treatment induced 100% mortality of Lm infected Cyld -/- mice, thus, resembling WT mice (XREF_FIG)."

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"Accordingly, knockdown of STAT3 significantly reduced serum IL-6 levels in Lm infected Cyld -/- mice as compared to mock treated infected Cyld -/- mice as well as untreated infected Cyld -/- mice (XREF_FIG)."

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"In this model inflammatory genes were activated by STAT3 mediated induction of miR-181b-1 that targets the tumor suppressor CYLD."

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STAT3 activates CYLD. 3 / 3

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