IndraLab

Statements

STAT3 activates CYLD. 4 / 4
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"Accordingly, knockdown of STAT3 significantly reduced serum IL-6 levels in Lm infected Cyld -/- mice as compared to mock treated infected Cyld -/- mice as well as untreated infected Cyld -/- mice (XREF_FIG)."
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"In this model inflammatory genes were activated by STAT3 mediated induction of miR-181b-1 that targets the tumor suppressor CYLD."
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"The high levels of STAT3 activation in CYLD LΔ/Δ mice from P60 and onward and the correlation of STAT3 activation with the levels of ROS accumulation provide a strong indication for its involvement in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22698400
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"Importantly, STAT3 siRNA treatment induced 100% mortality of Lm infected Cyld -/- mice, thus, resembling WT mice (XREF_FIG)."
23825949