IndraLab
Statements
eidos
"Since Smad2 must activate Smad4 to regulate the Smad downstream pathway , as expected , the deletion of Smad2 in LCs also displayed the interruption of long-term LC repopulation and the lower expression of EpCAM and CD24 on the long-term LCs , while short-term LCs were unaffected ."
reach
"Ligand binding and recruitment of TβRI activates its kinase that phosphorylates the carboxy-terminal serine residue of SMAD2 (SMAD Family Member 2) or SMAD3 (SMAD Family Member 3), which induces oligomerization of SMAD2 or SMAD3 with SMAD4 (SMAD Family Member 4), resulting in nuclear translocation for transcriptional activation or repression of target genes."
reach
"Through analyzing the publicly available algorithms, including TargetScan, miRWalk, and miRanda, we found that several components of TGF-beta signaling, including SMAD2, SMAD4, and TGFBRI, may be potential targets of miR-582-3p, and SMAD2, SMAD4, TGFBRI, and TGFBRII for miR-582-5p (XREF_SUPPLEMENTARY A-S4C)."
reach
"Activated TβRI kinase phosphorylates the carboxy-terminal serine residue of the mothers against DPP Homolog proteins SMAD2 or SMAD3, which induces oligomerization of SMAD2 or SMAD3 with SMAD4, and DNA binding of the complex to mediate transcriptional activation or repression of target genes."