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USPL1 desumoylates TRIM5. 1 / 1

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"Mechanistically, deSUMOylation of TRIM5α by the deSUMOylating enzyme USPL1 in Cajal bodies allows TRIM5α to be sequestered in the nucleus, leading to efficient type I interferon responses by the DNA sensor cGAS during retroviral infection."

38280996

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IndraLab

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USPL1 desumoylates TRIM5. 1 / 1

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