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USP22 activates STAT1. 2 / 2

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"Moreover, STAT1 pathway could be activated by down-regulation of USP22 in LUAD H1975 cell line (XREF_FIG), which can directly affect the formation of immune proteins and regulate JAK-STAT signaling pathway."

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"In mechanism, USP22 enhances the stability of STAT1 via deubiquitination and promotes the activation of IFNγ stimulation in melanoma [ 43 ]."

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IndraLab

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USP22 activates STAT1. 2 / 2

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