IndraLab

Statements

USP37 activates SAMHD1. 6 / 6
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"Further analysis showed that USP37 restored the inhibitory effect of Vpx on endogenous SAMHD1 (Fig. 8J)."
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"Furthermore, USP37 enhances antiviral efficacy and suppresses retrotransposition of LINE-1 elements by stabilizing SAMHD1."
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"In summary, USP37 enhances antiviral and anti-retrotransposition activities by stabilizing SAMHD1."
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"Deubiquitinase USP37 enhances the anti-HIV-2/SIV ability of the host restriction factor SAMHD1."
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"Interestingly, USP37 could enhanced the stability of SAMHD1 in the absence of Vpx or SAMHD1 mutant resistance to Vpx-mediated degradation (Fig. 5B)."
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"However, USP37 WT restored the ability of SAMHD1 to inhibit the LINE1 activity, but the C350A mutant only partially restored the SAMHD1 activity (Fig. 8I, lanes 5 and 6)."
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