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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP9X activates meiotic spindle assembly checkpoint. 3 / 3

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"USP9X thereby opposes activation of anaphase promoting complex and cyclosome (APC/C) and specifically inhibits the mitotic degradation of SAC controlled APC/C substrates."

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"This function is critical for mitotic fidelity because loss of USP9X causes a reduction in the efficiency of the SAC, an increased frequency of chromosome mis-segregations and the generation of chromosomal instability (CIN)."

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"USP9X Enhances SAC Efficiency to Protect against CIN."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

USP9X activates meiotic spindle assembly checkpoint. 3 / 3

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