IndraLab

Statements

USP9X activates meiotic spindle assembly checkpoint. 3 / 3

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"USP9X thereby opposes activation of anaphase promoting complex and cyclosome (APC/C) and specifically inhibits the mitotic degradation of SAC controlled APC/C substrates."

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"This function is critical for mitotic fidelity because loss of USP9X causes a reduction in the efficiency of the SAC, an increased frequency of chromosome mis-segregations and the generation of chromosomal instability (CIN)."

29669289

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"USP9X Enhances SAC Efficiency to Protect against CIN."

29669289

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

USP9X activates meiotic spindle assembly checkpoint. 3 / 3

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