IndraLab

Statements

USP8 increases the amount of CTNNB1. 6 / 6
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"USP8 depletion significantly decreased beta-catenin protein level, beta-catenin target genes expression and TOP-luciferase activity in HCC cells."
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"Consistently, overexpression of the wild-type USP8 significantly increased the expression of β-catenin in a dose-dependent manner."
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"Briefly, we transfected four nonoverlapping siRNA mixtures specific for each of the DUBs into LM3 cells and found that silencing USP8 significantly decreased β-catenin protein level in LM3 cells (Fig. 1A)."
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"While the catalytically inactive mutant C786A (USP8 ) could not increase β-catenin protein levels, indicating that USP8 increased β-catenin protein level depending on its DUB activity (Fig. 1F)."
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"Since USP8 interacted with β-catenin and USP8 depletion decreased β-catenin levels, we hypothesized that USP8 may regulate the turnover of β-catenin through the Ub-proteasome pathway."
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"Depletion of USP8 by two non-overlapping siRNAs separately markedly decreased β-catenin levels."
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