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KCNE5 inhibits KCNQ1. 7 / 8
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"However, Scn3a establishes a new negative correlation at 90/5 5 h with the pseudogene Kcne1l (Potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene), known to slow the activation of the Kcnq1 channel [31]."
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"This function is common to KCNE peptides, as indicated by Kv7 channels having a similar behavior; that is, KCNE1, KCNE4 and KCNE5 slow the activation of Kv7.1 and Kv7.5 channels [29,30]."
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"The KCNE5 gene product MiRP4 suppresses the IKs current and downregulates the beta-subunit of the KCNQ1."
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"KCNE5 also inhibits KCNQ1, shifting its voltage dependence by +140 mV such that it does not activate at physiologically relevant membrane potentials."
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"At room temperature, KCNE5 slowed KCNQ1 activation to a rate half of that observed for KCNQ1-KCNE1 and accelerated KCNQ1 deactivation."
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"At room temperature, KCNE5 slowed KCNQ1 activation to a rate half of that observed for KCNQ1-KCNE1 (XREF_FIG) and accelerated KCNQ1 deactivation."
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"KCNE4 and KCNE5, in contrast, each inhibit KCNQ1 activity; in the case of KCNE4 this effect involves calmodulin but probably not impaired trafficking [XREF_BIBR - XREF_BIBR], while the KCNE5 effect involves a positive-shift in the voltage dependence of activation [XREF_BIBR]."
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