IndraLab

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USP17L2 deubiquitinates SNAI2. 4 / 4
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"Dub3 deubiquitinates Slug and Twist."
29088851
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"In this study, we identified <span class="match term0">Dub3</span> as a novel DUB for both <span class="match term1">Slug</span> and Twist. We further found that <span class="match term0">Dub3</span> overexpression increased <span class="match term1">Slug</span> and Twist protein levels in a dose-dependent manner, whereas <span class="match term0">Dub3</span>-knockdown decreased their protein levels."
29088851
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"Such as, the crucial oncogene Slug is deubiquitinated and stabilized by DUB3 and USP10 [ 33 , 34 ]."
30763716
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"In addition, several discoveries have been made about the de-ubiquitination of EMT-TFs, i.e., Dub3 de-ubiquitinates Snail [59], Slug and Twist [22], whereas Trabid stabilizes Twist by cleaving RNF8-induced ubiquitination [21] and USP29 cooperates with phosphatase SCP1 to stabilize Snail [60]."
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