IndraLab

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Pyrimidine inhibits DDX58. 5 / 5
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"More recently, a pyrimidine inhibitor identified as a broadspectrum antiviral was found to activate RIG-I (Chung et al, 2016) , an essential cellular sensor to mount innate immune response in influenza virus infection (Loo et al, 2008) ."
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"However, we did not confirm this observation in HEK-293 cells (XREF_FIG and XREF_FIG and XREF_FIG), suggesting that RIG-I induction by pyrimidine biosynthesis inhibitors alone is cell type dependent."
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"However, we did not confirm this observation in HEK-293 cells (Fig. 7A and B and 8B), suggesting that RIG-I induction by pyrimidine biosynthesis inhibitors alone is cell type dependent."
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"After more extensive search, the only piece of supportive evidence we obtained so far is that a pyrimidine inhibitor identified as a broad-spectrum antiviral was found to activate RIG-I, an essential cellular sensor to mount innate immune response in virus infection, especially influenza virus infection."
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"More recently, it was shown that pyrimidine biosynthesis inhibitors could increase the expression of retinoic acid-inducible gene 1 (RIG-I), a cytoplasmic sensor inducing the expression of innate immunity genes and IFNs in response to RNA virus infections (16)."
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