IndraLab

Statements

KCNH3 activates autophagy. 4 / 4
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"NAF-1 is a component of the inositol-1,4,5 trisphosphate (IP3) receptor complex, which contributes to the interaction of Bcl-2 with Bec1 and is required for Bcl-2 to functionally antagonize Bec1 mediated autophagy."
20125189
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"Accordingly, the longevity extending effects of PNC-1 were lost upon the knockdown of SIR-2.1, as well as upon that of either of the two essential autophagy modulators BEC-1 or ATG-5 [XREF_BIBR]."
20157579
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"Alternatively, other functions of bec-1, such as endosome-to-Golgi retrograde transport, may be required to support long life, rather than autophagy."
26865495
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"Indeed, the initial step of autophagy, mediated by BEC-1 (Atg6, Homolog of Beclin-1) is crucial to correct dauer formation."
20087441