IndraLab

Statements

reach
"USP22 up-regulates the SIRT1/AKT/MRP1 signaling pathway and promotes the efflux of 5-Fluorouracil (5-FU), leading to the treatment resistance of HCC [17]."
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"This study further discovers that USP22 activated the SRC signaling pathway by upregulating the molecule KDEL endoplasmic reticulum protein retention receptor 1 (KDELR1), thereby contributing to LUAD cell progression."
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"Collectively, our findings indicate that miR-200b-5p-mediated inhibition of USP22 attenuates cell proliferation by targeting the NF-κB signaling pathway in GC, suggesting that miR-200b-5p and USP22 could serve as potential diagnostic or therapeutic targets for gastric cancer and other related human diseases."
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"These results indicated that USP22 deficiency reversed renal EMT and TIF in diabetic kidneys by blocking the Snail1 signaling pathway (see Fig. 11 )."
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"These results further validated that the tumors with Usp22 overexpression were significantly larger and more aggressive than those in the control group, whereas Usp22 ablation diminished this effect.2.2 USP22 activates the mTORC1 signaling pathway."
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"Inhibition of USP22 by miR-200b-5p represses gastric cancer cell proliferation and migration by targeting the NF-κB signaling pathway."
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"USP22 maintained GC cell stemness by stabilizing BMI1 and promoted proliferation and metastasis by activating the FOXO1 and YAP signaling pathway [47,50]."
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