IndraLab

Statements


CANX binds ABCA1 and nef. 4 / 4
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sparser
"We studied molecular details of Nefcalnexin and NefABCA1 interactions and identified a compound, which blocked Nefcalnexin interaction and partially restored ABCA1 activity in HIV-infected cells (Hunegnaw et al. xref ), modified the compound for better solubility (Adzhubei et al. xref ), and predicted a series of compounds for potential development as inhibitors of Nef-mediated co-morbidities of HIV infection by virtual screening (Adzhubei et al. xref )."

sparser
"We studied molecular details of Nefcalnexin and NefABCA1 interactions and identified a compound, which blocked Nefcalnexin interaction and partially restored ABCA1 activity in HIV-infected cells (Hunegnaw et al. 2016), modified the compound for better solubility (Adzhubei et al. 2018), and predicted a series of compounds for potential development as inhibitors of Nef-mediated co-morbidities of HIV infection by virtual screening (Adzhubei et al. 2021)."

sparser
"We studied molecular details of Nef-calnexin and Nef-ABCA1 interactions and identified a compound, which blocked Nef-calnexin interaction and partially restored ABCA1 activity in HIV-infected cells (Hunegnaw et al. 2016) , modified the compound for better solubility , and predicted a series of compounds for potential development as inhibitors of Nef-mediated co-morbidities of HIV infection by virtual screening (Adzhubei et al. 2021 )."

sparser
"Nef disrupted interaction between calnexin and ABCA1 but increased affinity and enhanced interaction of calnexin with HIV-1 gp160."