IndraLab

Statements

eidos
"In particular , Gal-SLPs can induce a trio synergetic effect : i ) sorafenib elevated intracellular levels of ROS , which oxidize B-PDEAEA to trigger rapid shUSP22 release for efficient gene downregulation ; ii ) the downregulation of USP22 led to downregulation of multidrug resistance-associated protein 1 ( MRP1 ) and inhibition of glycolysis , dramatically impairing MDR and achieving higher intracellular sorafenib accumulation , thus generating an ROS-responsive positive feedback loop ; iii ) the downregulation of USP22 suppressed the cell metabolism of cancer cells and further influenced cancer stemness ."
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"In the meantime, USP22 overexpression aggravated the EMT phenotype of TNBC cells, which revealed that USP22 contributes to the EMT process in TNBC.The causative role of glycolysis in stemness and EMT [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus , we speculated that the downregulation of USP22 by Gal-SLPs could block the glycolysis and further suppress stemness features in HCC cells ."
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"USP22 can stabilize HIF-1α by deubiquitination and promote glycolysis induced by the hypoxia and stemness of hepatocellular carcinoma (HCC) cells."
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"Overexpression of USP22 in HCC cell lines, under hypoxic conditions, significantly enhanced glycolysis, as it upregulated the mRNA expression of key glycolytic enzymes (HK2, PDK1, and ENO1)."
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"HIF-1α knock-down resulted in the abrogation of the USP22-enhanced cancer stemness and glycolysis under hypoxic conditions [92]."
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"USP22 promotes hypoxia induced HCC stemness and glycolysis by deubiquitinating and stabilising HIF1alpha."
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"Studies have identified that USP22 promotes glycolysis in HCC via the deubiquitination of HIF-1α and activates the de novo synthesis of fatty acids in HCC by deubiquitinating PPARγ [ 22 , 36 ]."
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"An illustrative example is the positive feedback loop between USP22 and HIF1α, which promotes glycolysis and stemness in HCC following TP53 mutation [94]."
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"USP22 Promotes Osteosarcoma Progression by Stabilising β-Catenin and Upregulating HK2 and Glycolysis."
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"To further explore the role of USP22-induced glycolysis in the chemoresistance, stemness, and EMT phenotype of DDP-resistant TNBC cells, 2-deoxy-d-glucose (2-DG, a specific glycolysis inhibitor) was e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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