IndraLab

Statements

reach
"USP22 promotes hypoxia induced HCC stemness and glycolysis by deubiquitinating and stabilising HIF1alpha."
31776228
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"USP22 contributes to chemoresistance, stemness, and EMT phenotype of TNBC cells by suppressing the glycolysis via c-Myc deubiquitination."
36528490
eidos
"In particular , Gal-SLPs can induce a trio synergetic effect : i ) sorafenib elevated intracellular levels of ROS , which oxidize B-PDEAEA to trigger rapid shUSP22 release for efficient gene downregulation ; ii ) the downregulation of USP22 led to downregulation of multidrug resistance-associated protein 1 ( MRP1 ) and inhibition of glycolysis , dramatically impairing MDR and achieving higher intracellular sorafenib accumulation , thus generating an ROS-responsive positive feedback loop ; iii ) the downregulation of USP22 suppressed the cell metabolism of cancer cells and further influenced cancer stemness ."
33717848
eidos
"Thus , we speculated that the downregulation of USP22 by Gal-SLPs could block the glycolysis and further suppress stemness features in HCC cells ."
33717848