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USP18 activates SLC15A1. 3 / 4
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"16, 23 A recent study found that USP18 can enhance the cellular transport rate in Xenopus laevis oocytes by increasing the activity of PEPT1 and PEPT2; this activation was believed to be due to the reversal of ubiquitination and the subsequent degradation of carrier protein."

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"XREF_BIBR, XREF_BIBR A recent study found that USP18 can enhance the cellular transport rate in Xenopus laevis oocytes by increasing the activity of PEPT1 and PEPT2; this activation was believed to be due to the reversal of ubiquitination and the subsequent degradation of carrier protein."

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"53 In addition to ISG15, USP18 also specifically inhibits K63-linked ubiquitination of NEMO, leading to the negative regulation of NF-κB activation induced by the TAK1-TAB complex.16, 23 A recent study found that USP18 can enhance the cellular transport rate in Xenopus laevis oocytes by increasing the activity of PEPT1 and PEPT2; this activation was believed to be due to the reversal of ubiquitination and the subsequent degradation of carrier protein.54The innate immune system reduces viral replication via IFN-I; this reduction is essential for inhibiting the spread of virus to other organs."